Report on the Study Leave of a Faculty Member from the Department of Biology, Lorestan University / The Application of Science for the Improvement of Human Quality of Life
Jun 01, 2026
In line with strengthening academic collaborations with society and industry, a seminar reporting on the sabbatical leave of Dr. Vali Akbari, a faculty member of the Biology Department at Lorestan University, was held virtually on Saturday, May 23, 2026, at 9 AM.
This session, focusing on "Nanoencapsulation of Saccharomyces boulardii Supernatant in Alginate/-β-Cyclodextrin Nanoparticles and Investigation of its Antibacterial, Antioxidant, and Anticancer Effects," evaluated the synthesis and characterization of encapsulated nanoparticles, as well as their antioxidant, antibacterial, and anticancer effects on gastric cancer cell lines.
The primary objective of this period was the synthesis and characterization of encapsulated nanoparticles and the evaluation of their antioxidant, antibacterial, and anticancer effects on gastric cancer cell lines. The alginate-/β-cyclodextrin-based microencapsulation of Saccharomyces boulardii, developed in this study, offers a multifunctional strategy to overcome stability, viability, and functionality limitations in probiotics and holds significant potential for reducing probiotic loss due to gastrointestinal conditions.
The most significant innovation of this research lies in the design and development of a novel, biocompatible nanocarrier system based on the combination of alginate and β-cyclodextrin polymers for the encapsulation of the probiotic yeast Saccharomyces boulardii supernatant. This is the first study of its kind to simultaneously evaluate the antibacterial, antioxidant, and anticancer effects of this nanoformulation on the AGS gastric cancer cell line.
This combined approach, while maintaining high probiotic viability under acidic gastric conditions and in the presence of bile salts, can serve as a multifunctional platform for the production of functional products with industrial applications in functional beverages, dietary supplements, fermented dairy products, and bioactive packaging.
Source of news text data: Lorestan University's Office of Community and Industry Relations.
